fusionDB
Example Visualizations
Below are example organism selections that show the power of fusion visualizations. Be aware that the visualization is generated on demand and might take some time until being created.
  • Hints of horizontal gene transfer

    This example is a recreation of case study 2 (Figure 4) in the original publication of fusionDB [add reference here]. Recoloring the visualization by temperature preference shows clear separation between mesophiles and thermophiles. Investigating the graph in interactive visualization mode we can observe that the three Bacilli organism that are thermophilic are functionally closer to the thermophilic Clostridia organisms then to other evolutionary closer related mesophilic Bacilli.


    Organism Genus Temperature Preference
    Bacillus amyloliquefaciens DSM 7 Bacilli Mesophile
    Bacillus anthracis A0248 Bacilli Mesophile
    Bacillus cereus ATCC 14579 Bacilli Mesophile
    Bacillus coagulans 2 6 Bacilli Thermophile
    Bacillus coagulans 36D1 Bacilli Thermophile
    Bacillus licheniformis ATCC 14580 Bacilli Mesophile
    Bacillus megaterium DSM319 Bacilli Mesophile
    Bacillus subtilis 168 Bacilli Mesophile
    Bacillus thuringiensis Al Hakam Bacilli Mesophile
    Bacillus tusciae DSM 2912 Bacilli Thermophile
    Bacillus weihenstephanensis KBAB4 Bacilli Psychrotolerant
    Desulfotomaculum carboxydivorans CO 1 SRB Clostridia Thermophile
    Sulfobacillus acidophilus TPY Clostridia Thermophile

  • Mapping a previously unknown Synechococcus into fusionDB

    In this example we chose to map a Synechococcus that is presently not in fusionDB. Coloring the fusion+ visualization by habitat preference a clear separation into marine and fresh water organisms is visible, with the exception of one organism. Using the interactive display we were able to extract exactly which organism this is (Synechococcus PCC 7002), with the information that this microbe was actually extracted from marine mud. Further investigation in available literature revealed that this organism despite being salt tolerant does not require salt to grow, and therefore possibly has a closer functional relatedness to fresh water organisms than marine organisms. Additionally the query organism (of which it is known that this Synechococcus is extracted from a fresh water enviroment) clusters well with other fresh water Synechococcus. Functional relatedness to other organisms and the functional repertoire this Synechococcus was mapped to can also be investigated here.


    Organism Habitat
    Synechococcus PCC 7502 (Query) Fresh water
    Synechococcus PCC 7002 Marine (Mud)
    Synechococcus elongatus PCC 7942 Fresh water
    Synechococcus elongatus PCC 6301 Fresh water
    Synechococcus JA 2 3B a 2 13 Fresh water
    Synechococcus JA 3 3Ab Fresh water
    Synechococcus WH 8102 Marine
    Synechococcus CC9311 Marine
    Synechococcus RCC307 Marine
    Synechococcus WH 7803 Marine
    Synechococcus CC9605 Marine
    Synechococcus CC9902 Marine